Author: Randall Toy; Pallab Pradhan; Vijayeetha Ramesh; Nelson C. Di Paolo; Blake Lash; Jiaying Liu; Emmeline L. Blanchard; Philip J. Santangelo; Dmitry M. Shayakhmetov; Krishnendu Roy
Title: Modification of primary amines to higher order amines reduces in vivo hematological and immunotoxicity of cationic nanocarriers through TLR4 and complement pathways Document date: 2019_5_24
ID: cbit5xci_31
Snippet: Next, we evaluated how IAA modification affects bPEI nanoparticle organ biodistribution, immune cell activation in the spleen, and complement activation. Unmodified, fluorescently labeled bPEI nanoparticles accumulated in the liver, kidney, and lungs one hour after IV injection. The unmodified bPEI nanoparticles remained in these organs 24 hours after injection......
Document: Next, we evaluated how IAA modification affects bPEI nanoparticle organ biodistribution, immune cell activation in the spleen, and complement activation. Unmodified, fluorescently labeled bPEI nanoparticles accumulated in the liver, kidney, and lungs one hour after IV injection. The unmodified bPEI nanoparticles remained in these organs 24 hours after injection.
Search related documents:
Co phrase search for related documents- bPEI nanoparticle and IV injection: 1
- cell activation and complement activation: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- cell activation and organ remain: 1
- cell activation and spleen cell activation: 1, 2, 3, 4
- complement activation and iaa modification: 1, 2, 3
- complement activation and organ remain: 1
Co phrase search for related documents, hyperlinks ordered by date