Selected article for: "immune system and innate immune system"
Author: Danielle E Anderson; Jin Cui; Qian Ye; Baoying Huang; Wenhong Zu; Jing Gong; Weiqiang Liu; So Young Kim; Biao Guo Yan; Kristmundur Sigmundsson; Xiao Fang Lim; Fei Ye; Peihua Niu; Xuming Zhou; Wenjie Tan; Lin-Fa Wang; Xu Tan
Title: Orthogonal genome-wide screenings in bat cells identify MTHFD1 as a target of broad antiviral therapy
  • Document date: 2020_3_30
    • ID: 0l33i6s4_1
    Snippet: Bats are responsible for the zoonotic transmission of several major viral diseases including the 2 2003 SARS outbreak and the ongoing COVID-19 pandemic. While bat genomic sequencing 3 studies have revealed characteristic adaptations of the innate immune system, functional genomic 4 studies are urgently needed to provide a foundation for the molecular dissection of the tolerance 5 of viral infections in bats. Here we report the establishment and s.....
    Document: Bats are responsible for the zoonotic transmission of several major viral diseases including the 2 2003 SARS outbreak and the ongoing COVID-19 pandemic. While bat genomic sequencing 3 studies have revealed characteristic adaptations of the innate immune system, functional genomic 4 studies are urgently needed to provide a foundation for the molecular dissection of the tolerance 5 of viral infections in bats. Here we report the establishment and screening of genome-wide RNAi 6 library and CRISPR library for the model megabat, Pteropus Alecto. We used the complementary 7

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