Author: Tayaza Fadason; Sreemol Gokuladhas; Evgeniia Golovina; Daniel Ho; Sophie Farrow; Denis Nyaga; Hong Pan; Neerja Karnani; Conroy Wong; Antony Cooper; William Schierding; Justin M. O’Sullivan
Title: A transcription regulatory network within the ACE2 locus may promote a pro-viral environment for SARS-CoV-2 by modulating expression of host factors Document date: 2020_4_15
ID: 5r0u2mmo_28
Snippet: We hypothesize that this regulatory change extends to coordinate changes in the expression of 197 VSP13C and PHKA2 in ways that promote viral proliferation. This host regulatory network has 198 not evolved to benefit the virus but rather, these regulatory changes inadvertently produce an 199 environment advantageous for the virus. The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.04.14.0420.....
Document: We hypothesize that this regulatory change extends to coordinate changes in the expression of 197 VSP13C and PHKA2 in ways that promote viral proliferation. This host regulatory network has 198 not evolved to benefit the virus but rather, these regulatory changes inadvertently produce an 199 environment advantageous for the virus. The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.04.14.042002 doi: bioRxiv preprint the suggestion that carbonic anhydrase inhibitors could be used to treat or prevent Covid-19 214 infection [43] . 215
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