Author: Luczkowiak, Joanna; Labiod, Nuria; Rivas, Gonzalo; Rolo, Marta; Lasala, Fátima; Lora-Tamayo, Jaime; Mancheno-Losa, Mikel; Rial, David; Pérez-Rivilla, Alfredo; Folgueira, MarÃa D; Delgado, Rafael
Title: Prime-boost vaccination with BNT162b2 induces high neutralizing activity against SARS-CoV-2 variants in naïve and COVID-19 convalescent individuals Cord-id: kkohr5a3 Document date: 2021_9_24
ID: kkohr5a3
Snippet: OBJECTIVES: To investigate the neutralizing response against SARS-CoV-2 Variants of Concern (VoC) during COVID-19 convalescence and after vaccination. METHODS: COVID-19 convalescents and naïve individuals were tested for neutralizing activity against SARS-CoV-2 VoC Alpha, Beta, Gamma and Delta at 1- and 7-months post-infection and 4-6 weeks after BNT162b2 vaccination. RESULTS: Vaccination induced a high neutralizing response in naïve individuals. Interestingly, vaccination of convalescent pati
Document: OBJECTIVES: To investigate the neutralizing response against SARS-CoV-2 Variants of Concern (VoC) during COVID-19 convalescence and after vaccination. METHODS: COVID-19 convalescents and naïve individuals were tested for neutralizing activity against SARS-CoV-2 VoC Alpha, Beta, Gamma and Delta at 1- and 7-months post-infection and 4-6 weeks after BNT162b2 vaccination. RESULTS: Vaccination induced a high neutralizing response in naïve individuals. Interestingly, vaccination of convalescent patients induced a boosting response that was able to neutralize all VoC at high titers. CONCLUSIONS: Vaccination with BNT162b2 induced high levels of neutralization against SARS-CoV-2 VoC in most patients, this is especially beneficial in COVID-19 convalescent individuals.
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