Author: Arlin Stoltzfus; Ryan W. Norris
Title: On the causes of evolutionary transition:transversion bias Document date: 2015_9_28
ID: 4xocqn6o_18
Snippet: The results of using EX, U and a cross-validation predictor (Table 1) indicate that even small studies of mutant fitnesses have considerable power to reveal generic effects of amino acid exchangeability. For instance, for the study of 135 HIV capsid mutants by Rihn, et al., there is a significant correlation between the fitness reported for a mutant and the predictor for the relevant replacement type (e.g., Val to Ala), whether the predictor is E.....
Document: The results of using EX, U and a cross-validation predictor (Table 1) indicate that even small studies of mutant fitnesses have considerable power to reveal generic effects of amino acid exchangeability. For instance, for the study of 135 HIV capsid mutants by Rihn, et al., there is a significant correlation between the fitness reported for a mutant and the predictor for the relevant replacement type (e.g., Val to Ala), whether the predictor is EX, U, or a cross-validation predictor based on the other studies. This shows, not only that individual studies are powerful, but that there is a consistency across studies: although most effects of an amino acid replacement in a protein are very context-dependent (which is why the R 2 values are small), generic effects of exchangeability are seen across sites and proteins.
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