Author: Hall, Mark W; Joshi, Ila; Leal, Luis; Ooi, Eng Eong
Title: Immune modulation in COVID-19: Strategic considerations for personalized therapeutic intervention Cord-id: zlro6tel Document date: 2020_7_1
ID: zlro6tel
Snippet: We are learning that the host response to SARS-CoV-2 infection is complex and highly dynamic. Effective initial host defense in the lung is associated with mild symptoms and disease resolution. Viral evasion of the immune response can lead to refractory alveolar damage, ineffective lung repair mechanisms, and systemic inflammation with associated organ dysfunction. The immune response in these patients is highly variable and can include moderate to severe systemic inflammation and/or marked syst
Document: We are learning that the host response to SARS-CoV-2 infection is complex and highly dynamic. Effective initial host defense in the lung is associated with mild symptoms and disease resolution. Viral evasion of the immune response can lead to refractory alveolar damage, ineffective lung repair mechanisms, and systemic inflammation with associated organ dysfunction. The immune response in these patients is highly variable and can include moderate to severe systemic inflammation and/or marked systemic immune suppression. There is unlikely to be a “one size fits all†approach to immunomodulation in patients with COVID-19. We believe that a personalized, immunophenotype-driven approach to immunomodulation that may include anti-cytokine therapy in carefully selected patients and immunostimulatory therapies in others is the shortest path to success in the study and treatment of patients with critical illness due to COVID-19.
Search related documents:
Co phrase search for related documents- activated neutrophil and acute ards respiratory distress syndrome: 1, 2, 3, 4, 5, 6, 7
- activated neutrophil and acute lung injury: 1, 2, 3, 4, 5
- activated neutrophil and acute respiratory syndrome: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17
- activation recruitment and acute ards respiratory distress syndrome: 1, 2, 3, 4, 5, 6, 7, 8
- activation recruitment and acute lung injury: 1, 2, 3, 4, 5, 6, 7, 8, 9
- activation recruitment and acute respiratory syndrome: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20
- activation recruitment and adaptive immune response: 1, 2, 3, 4
- activation recruitment and adaptive immune suppression: 1
- activation recruitment and local immune response: 1
- active trial and acute lung injury: 1
- active trial and acute respiratory syndrome: 1, 2
- acute ards respiratory distress syndrome and adaptive immune response: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11
- acute lung injury and adaptive immune response: 1, 2, 3, 4, 5
- acute lung injury and additional approach: 1
- acute respiratory syndrome and adaptive immune dysfunction: 1
- acute respiratory syndrome and adaptive immune response: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- acute respiratory syndrome and adaptive immune suppression: 1, 2
- acute respiratory syndrome and additional approach: 1, 2, 3, 4
- acute respiratory syndrome and local immune response: 1, 2, 3, 4, 5, 6
Co phrase search for related documents, hyperlinks ordered by date