Selected article for: "acute infection and virus specific cell"
Author: Grau-Expósito, Judith; Sánchez-Gaona, Nerea; Massana, Núria; Suppi, Marina; Astorga-Gamaza, Antonio; Perea, David; Rosado, Joel; Falcó, Anna; Kirkegaard, Cristina; Torrella, Ariadna; Planas, Bibiana; Navarro, Jordi; Suanzes, Paula; Álvarez-Sierra, Daniel; Ayora, Alfonso; Sansano, Irene; Esperalba, Juliana; Andrés, Cristina; Antón, Andrés; Ramón y Cajal, Santiago; Almirante, Benito; Pujol-Borrell, Ricardo; Falcó, Vicenç; Burgos, Joaquín; Buzón, María J.; Genescà, Meritxell
Title: Peripheral and lung resident memory T cell responses against SARS-CoV-2
  • Cord-id: jpys7epv
  • Document date: 2021_5_21
    • ID: jpys7epv
    Snippet: Resident memory T cells (T(RM)) positioned within the respiratory tract are probably required to limit SARS-CoV-2 spread and COVID-19. Importantly, T(RM) are mostly non-recirculating, which reduces the window of opportunity to examine these cells in the blood as they move to the lung parenchyma. Here, we identify circulating virus-specific T cell responses during acute infection with functional, migratory and apoptotic patterns modulated by viral proteins and associated with clinical outcome. Di
    Document: Resident memory T cells (T(RM)) positioned within the respiratory tract are probably required to limit SARS-CoV-2 spread and COVID-19. Importantly, T(RM) are mostly non-recirculating, which reduces the window of opportunity to examine these cells in the blood as they move to the lung parenchyma. Here, we identify circulating virus-specific T cell responses during acute infection with functional, migratory and apoptotic patterns modulated by viral proteins and associated with clinical outcome. Disease severity is associated predominantly with IFNγ and IL-4 responses, increased responses against S peptides and apoptosis, whereas non-hospitalized patients have increased IL-12p70 levels, degranulation in response to N peptides and SARS-CoV-2-specific CCR7(+) T cells secreting IL-10. In convalescent patients, lung-T(RM) are frequently detected even 10 months after initial infection, in which contemporaneous blood does not reflect tissue-resident profiles. Our study highlights a balanced anti-inflammatory antiviral response associated with a better outcome and persisting T(RM) cells as important for future protection against SARS-CoV-2 infection.

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