Author: Ashish Goyal; E. Fabian Cardozo-Ojeda; Joshua T Schiffer
Title: Potency and timing of antiviral therapy as determinants of duration of SARS CoV-2 shedding and intensity of inflammatory response Document date: 2020_4_14
ID: d7stppv5_11
Snippet: We developed a pharmacokinetic / pharmacodynamic model of remdesivir (Fig. 3a) , a broad-spectrum nucleotide analogue that targets SARS CoV-2 replication in infected cells (16) . The model links intravenous administration with plasma levels of free drug and concentrations of the drug's active nucleotide-triphosphate component (NTP) observed within PBMCs in nonhuman primates (17) , and captures the slow decay of NTP within this compartment (Fig. 3.....
Document: We developed a pharmacokinetic / pharmacodynamic model of remdesivir (Fig. 3a) , a broad-spectrum nucleotide analogue that targets SARS CoV-2 replication in infected cells (16) . The model links intravenous administration with plasma levels of free drug and concentrations of the drug's active nucleotide-triphosphate component (NTP) observed within PBMCs in nonhuman primates (17) , and captures the slow decay of NTP within this compartment (Fig. 3b) .
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