Author: Ashish Goyal; E. Fabian Cardozo-Ojeda; Joshua T Schiffer
Title: Potency and timing of antiviral therapy as determinants of duration of SARS CoV-2 shedding and intensity of inflammatory response Document date: 2020_4_14
ID: d7stppv5_19
Snippet: We next performed simulations of therapy at very early timepoints during infection at and prior to peak viral load. Most infected people are pre-symptomatic at this stage so these model realizations may most closely reflect implementation of a post exposure prophylaxis strategy in which some people are already in the very early stages of infection at the time of first dose. Under this scenario, extremely potent (EC50=0.8 uM) therapies at day 2 an.....
Document: We next performed simulations of therapy at very early timepoints during infection at and prior to peak viral load. Most infected people are pre-symptomatic at this stage so these model realizations may most closely reflect implementation of a post exposure prophylaxis strategy in which some people are already in the very early stages of infection at the time of first dose. Under this scenario, extremely potent (EC50=0.8 uM) therapies at day 2 and 0 of infection resulted in immediate viral suppression (Fig. 4c, d) . With early, low or moderate potency treatment, the model predicted therapeutic failure with persistent SARS CoV-2 shedding due to insufficient early immunity against the virus (Fig. 4d) .
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