Parents' Perspective of Antibiotic Usage in Children: A Nationwide Survey in Italy.

Pierantoni, Luca; Lo Vecchio, Andrea; Lenzi, Jacopo; Corsi, Vincenza; Campana, Lara; Luca Trobia, Gian; Amendolea, Antonella; Di Felice, Benedetta; Alighieri, Giovanni; Fabrizio, Giovanna Carmela; Bisceglia, Massimo; Peia, Francesco; Chiale, Federica; Bartolomei, Beatrice; Siciliano, Chiara; Di Battista, Caterina; Passone, Eva; di Giovanni, Chiara; Piergentili, Edward; Donà , Daniele; Buonsenso, Danilo

BACKGROUND Antibiotics represent the most widely prescribed drugs in children worldwide, both in hospital and community settings. A comprehensive approach to understanding the reasons and determinants of antibiotic prescription in the pediatric age is needed. This study aimed to assess parents' attitudes and perspectives about antibiotic use. METHODS Prospective observational study was conducted in all Italian Regions between February 1 and April 30, 2020, using a standardized questionnaire. RESULTS Six thousand six hundred twenty-five parents from all Italian regions completed the survey. Seventy-six percent of parents were aware that only bacteria are the target of antibiotics, but 92.9% knew that the antibiotic has no direct effect on fever. Antibiotic self-prescription (10.4%) or by remote consultation by phone call (19.9%) or message (9.6%) were relatively common. Ninety-three percent of parents were aware that excessive use of antibiotics could select resistant bacteria and 84.7% of them knew that they could actively fight antibiotic resistance. About two thirds of participants (66.1%) received information on antibiotic resistance from their family pediatrician. Parents born of Italy or those with lower income had a higher probability of having less information from pediatricians or knowledge of proper antibiotic use. DISCUSSION Our study suggests that parents' knowledge and attitudes toward antibiotic use and prescription are improving compared with previous studies, while there is still a gap regarding antibiotic resistance, particularly on practices that can reduce its burden. Our study's negative finding is that families from low-income settings or those born abroad have significantly more misconceptions about important antibiotic practices.