Author: Xiankun Zeng; Jun Liu; April Babka; Brian Kearney; Sheli Radoshitzky; Jens Kuhn
Title: Molecular Detection of SARS-CoV-2 in Formalin Fixed Paraffin Embedded Specimens Document date: 2020_4_22
ID: nzwe7hpg_7
Snippet: SARS-CoV-2 detection in FFPE specimens 4 dyspnea, and myalgia with medium incubation period of 4 days (13-15). Ground-glass opacity is 52 the most common radiologic finding on chest CT upon admission (13) (14) (15) . Bilateral diffuse 53 alveolar damage, alveolar hemorrhage and edema, interstitial fibrosis and inflammation, and type 54 II pneumocyte hyperplasia are observed in post-mortem human lungs (16) (17) (18) . 55 At the time of writing, th.....
Document: SARS-CoV-2 detection in FFPE specimens 4 dyspnea, and myalgia with medium incubation period of 4 days (13-15). Ground-glass opacity is 52 the most common radiologic finding on chest CT upon admission (13) (14) (15) . Bilateral diffuse 53 alveolar damage, alveolar hemorrhage and edema, interstitial fibrosis and inflammation, and type 54 II pneumocyte hyperplasia are observed in post-mortem human lungs (16) (17) (18) . 55 At the time of writing, there are no animal models that truly mimic the disease spectrum and 56 pathogenesis of COVID-19. However, small animals (e.g., human ACE2 transgenic laboratory 57 mice (19), cats (20), domestic ferrets (20, 21), golden hamsters (22)), and nonhuman primates 58 (e.g., rhesus monkeys (23, 24), crab-eating macaques (25)), are used to study SARS-CoV-2 59 infection as alveolar damage, interstitial inflammation, and viral shedding occur in these animal 60 models to various degree. It is hoped that further development of these and other animal models 61 will help overcome the current roadblock to evaluating the efficacy of candidate medical 62 countermeasures (MCMs) against and the pathogenesis of COVID-19.
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