Author: Andreakos, Evangelos; Papadaki, Maria; Serhan, Charles N.
Title: Dexamethasone, proâ€resolving lipid mediators and resolution of inflammation in COVIDâ€19 Cord-id: k4mlkhu6 Document date: 2020_9_21
ID: k4mlkhu6
Snippet: Coronavirus diseaseâ€19 (COVIDâ€19) is a new disease caused by SARSâ€CoVâ€2. Since the beginning of 2020, it has become one of the main challenges of our times, causing a high incidence of severe pneumonia, acute respiratory distress syndrome (ARDS), multiorgan failure and death(1). At the root of COVIDâ€19 lies the sudden development of ‘cytokine storms’, hyperâ€inflammatory responses involving the release of proâ€inflammatory cytokines (e.g., TNF, ILâ€6, ILâ€1, ILâ€8, and MCPâ€1
Document: Coronavirus diseaseâ€19 (COVIDâ€19) is a new disease caused by SARSâ€CoVâ€2. Since the beginning of 2020, it has become one of the main challenges of our times, causing a high incidence of severe pneumonia, acute respiratory distress syndrome (ARDS), multiorgan failure and death(1). At the root of COVIDâ€19 lies the sudden development of ‘cytokine storms’, hyperâ€inflammatory responses involving the release of proâ€inflammatory cytokines (e.g., TNF, ILâ€6, ILâ€1, ILâ€8, and MCPâ€1) that impair the gas exchange function of the lung and lead in select patients, mostly with underlying comorbidities, to multiorgan failure and death.
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