Author: Tao, Sijia; Zandi, Keivan; Bassit, Leda; Ong, Yee Tsuey; Verma, Kiran; Liu, Peng; Downs-Bowen, Jessica A.; McBrayer, Tamara; LeCher, Julia C.; Kohler, James J.; Tedbury, Philip R.; Kim, Baek; Amblard, Franck; Sarafianos, Stefan G.; Schinazi, Raymond F.
Title: Comparison of anti-SARS-CoV-2 activity and intracellular metabolism of remdesivir and its parent nucleoside Cord-id: n4g9odh7 Document date: 2021_8_12
ID: n4g9odh7
Snippet: Remdesivir, a monophosphate prodrug of nucleoside analog GS-441524, is widely used for the treatment of moderate to severe COVID-19. It has been suggested to use GS-441524 instead of remdesivir in the clinic and in new inhalation formulations. Thus, we compared the anti-SARS-CoV-2 activity of remdesivir and GS-441524 in Vero E6, Vero CCL-81, Calu-3, Caco-2 cells, and anti-HCoV-OC43 activity in Huh-7 cells. We also compared the cellular pharmacology of these two compounds in Vero E6, Vero CCL-81,
Document: Remdesivir, a monophosphate prodrug of nucleoside analog GS-441524, is widely used for the treatment of moderate to severe COVID-19. It has been suggested to use GS-441524 instead of remdesivir in the clinic and in new inhalation formulations. Thus, we compared the anti-SARS-CoV-2 activity of remdesivir and GS-441524 in Vero E6, Vero CCL-81, Calu-3, Caco-2 cells, and anti-HCoV-OC43 activity in Huh-7 cells. We also compared the cellular pharmacology of these two compounds in Vero E6, Vero CCL-81, Calu-3, Caco-2, Huh-7, 293T, BHK-21, 3T3 and human airway epithelial (HAE) cells. Overall, remdesivir exhibited greater potency and superior intracellular metabolism than GS-441524 except in Vero E6 and Vero CCL-81 cells.
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