Author: Sarah Krieg; Fabian Pott; Laura Eckei; Maud Verheirstraeten; Mareike Bütepage; Barbara Lippok; Christine Goffinet; Bernhard Lüscher; Patricia Verheugd
Title: Mono-ADP-ribosylation by ARTD10 restricts Chikungunya virus replication by interfering with the proteolytic activity of nsP2 Document date: 2020_1_8
ID: 2vecg9op_9
Snippet: Further, the analysis of nsP3 revealed an increase in its processed form (Fig. 3m,n) , indicating 254 that the co-expression of the GFP-nanobody-nsP3-macrodomain at least to some extend was 255 able to rescue the CHIKV replicon lacking hydrolase activity. 256 257 Taken together, these data suggest strongly that polyprotein synthesis of the different 258 mutated replicons occurs and further support the hypothesis that MARylation affects 259 polypr.....
Document: Further, the analysis of nsP3 revealed an increase in its processed form (Fig. 3m,n) , indicating 254 that the co-expression of the GFP-nanobody-nsP3-macrodomain at least to some extend was 255 able to rescue the CHIKV replicon lacking hydrolase activity. 256 257 Taken together, these data suggest strongly that polyprotein synthesis of the different 258 mutated replicons occurs and further support the hypothesis that MARylation affects 259 polyprotein processing. 260 . CC-BY-NC-ND 4.0 International license author/funder. It is made available under a The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.01.07.896977 doi: bioRxiv preprint
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