Patient-derived mutations impact pathogenicity of SARS-CoV-2

Hangping Yao; Xiangyun Lu; Qiong Chen; Kaijin Xu; Yu Chen; Linfang Cheng; Fumin Liu; Zhigang Wu; Haibo Wu; Changzhong Jin; Min Zheng; Nanping Wu; Chao Jiang; Lanjuan Li

The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.04.14.20060160 doi: medRxiv preprint 3 outbreak. As of April 7, 2020, SARS-CoV-2 has infected more than 1.3 million people 35 around the world with a death toll of 70,000. The numbers are still increasing rapidly. 36 The estimate of the incubation period of SARS-CoV-2 (mean, 5.1 days; range, 4.5 to 5.8 37 days) (Lauer et al., 2020) is in line with those of other known human coronaviruses, such 38 as SARS (mean, 5 days; range, 2 to 14 days) (Varia et al., 2003) and MERS (mean, 5 to 7 39 days; range, 2 to 14 days) (Virlogeux et al., 2016) . The reproductive number of 40 SARS-CoV-2 is likely to be from 1.4 to 6.5, with a mean of 3.3 , which 41 is slightly higher than SARS, i.e. author/funder, who has granted medRxiv a license to display the preprint in perpetuity.