Author: Zachary J. Sandler; Michelle N. Vu; Vineet D. Menachery; Bryan C. Mounce
Title: Novel ionophores active against La Crosse virus identified through rapid antiviral screening Document date: 2020_1_23
ID: f1ixbzx8_2
Snippet: We expanded our results to additional ionophores, observing that some but not all effectively 106 blocked LACV replication. Finally, we determined that valinomycin is broadly antiviral, as it 107 reduced replication of several viruses from diverse families, including flaviviruses and 108 enteroviruses. Together, these data highlight the utility in rapid screening of antiviral molecules 109 as well as a crucial role for potassium ions in LACV infe.....
Document: We expanded our results to additional ionophores, observing that some but not all effectively 106 blocked LACV replication. Finally, we determined that valinomycin is broadly antiviral, as it 107 reduced replication of several viruses from diverse families, including flaviviruses and 108 enteroviruses. Together, these data highlight the utility in rapid screening of antiviral molecules 109 as well as a crucial role for potassium ions in LACV infection. 110
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