Natural Derived Nasal Spray; a Proposed Approach for COVID-19 Disease Control.

Hoseini-Tavassol, Zahra; Ejtahed, Hanieh-Sadat; Soroush, Ahmad-Reza; Sajjadpour, Zahra; Hasani-Ranjbar, Shirin; Larijani, Bagher

Considering the importance of COVID-19 disease pandemic, emerged by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), in line with other studies to find appropriate prevention or treatment methods for this virus infection, proposing the use of natural derived ingredients as an approach for COVID-19 disease control was our study objective. Here we reviewed previous studies on natural derived nasal sprays and found that some known natural derived ingredients have antiviral properties, so their topical use as a nasal spray is effective in reducing the symptoms of respiratory infections, and it also has potential of decreasing viral load including titer of coronaviruses, in the nasal cavity. It seems that use of carrageenan or other herbal ingredients nasal spray may block the SARS-CoV-2 virus entering to the lung cells of a contaminated person and also can prevent virus transmission to other susceptible persons. Further, noticing what we know about novel 2019 coronavirus so far, we suggested carrageenan that has an unspecific physical antiviral activity and some other natural derived ingredients as a choice in coping with SARS-CoV-2 virus infection.