Author: D’Alonzo, Daniele; De Fenza, Maria; Pavone, Vincenzo
Title: COVID-19 and pneumonia: a role for the uPA/uPAR system Cord-id: n5cppi72 Document date: 2020_6_18
ID: n5cppi72
Snippet: Here, we highlight recent findings on the urokinase plasminogen activator (uPA)/uPA receptor (uPAR) system that suggest its potential role as a main orchestrator of fatal progression to pulmonary, kidney, and heart failure in patients with coronavirus. Patients with prolonged background inflammation can present with aberrant inflammatory reactions, well recognized as the main factors that can result in death and probably sustained by a dysregulated uPA/uPAR system. SuPAR, the soluble form of uPA
Document: Here, we highlight recent findings on the urokinase plasminogen activator (uPA)/uPA receptor (uPAR) system that suggest its potential role as a main orchestrator of fatal progression to pulmonary, kidney, and heart failure in patients with coronavirus. Patients with prolonged background inflammation can present with aberrant inflammatory reactions, well recognized as the main factors that can result in death and probably sustained by a dysregulated uPA/uPAR system. SuPAR, the soluble form of uPAR, represents a biomarker of disease progression, and its levels correlate well with comorbidities associated with the death of patients with coronavirus. New drugs that regulate the uPA/uPAR system could help treat the severe complications of highly pathogenic human coronaviruses (hCoVs), including pandemic coronavirus 2019 (COVID-19).
Search related documents:
Co phrase search for related documents- aberrant immune response and lung injury: 1
- aberrant immune response and lupus erythematosus: 1, 2
- abnormal expression and activator signal transducer: 1
- abnormal expression and acute respiratory syndrome: 1, 2, 3, 4, 5
- abnormal expression and lung injury: 1, 2, 3
- abnormal expression and lupus erythematosus: 1
Co phrase search for related documents, hyperlinks ordered by date