Author: Aran Singanayagam; Joseph Footitt; Benjamin T Kasdorf; Matthias Marczynski; Michael T Cross; Lydia J Finney; Maria-Belen Trujillo Torralbo; Maria Calderazzo; Jie Zhu; Julia Aniscenko; Thomas B Clarke; Philip L Molyneaux; Nathan W Bartlett; Miriam F Moffatt; William O Cookson; Jadwiga Wedzicha; Christopher M Evans; Oliver Lieleg; Patrick Mallia; Sebastian L Johnston
Title: MUC5AC drives COPD exacerbation severity through amplification of virus-induced airway inflammation Document date: 2019_7_22
ID: gg2ctmn7_38
Snippet: The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/706804 doi: bioRxiv preprint effects during RV-induced COPD exacerbations. Rhinoviruses induce MUC5AC expression through EGFR signalling 23 . We therefore assessed the effect of EGFR inhibition in a mouse model of elastase-induced emphysema combined with RV-infection in which many features of human COPD exacerbation including mucus hypersecretion.....
Document: The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/706804 doi: bioRxiv preprint effects during RV-induced COPD exacerbations. Rhinoviruses induce MUC5AC expression through EGFR signalling 23 . We therefore assessed the effect of EGFR inhibition in a mouse model of elastase-induced emphysema combined with RV-infection in which many features of human COPD exacerbation including mucus hypersecretion are recapitulated 24 .
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