Selected article for: "central role and COPD exacerbation severity"
Author: Aran Singanayagam; Joseph Footitt; Benjamin T Kasdorf; Matthias Marczynski; Michael T Cross; Lydia J Finney; Maria-Belen Trujillo Torralbo; Maria Calderazzo; Jie Zhu; Julia Aniscenko; Thomas B Clarke; Philip L Molyneaux; Nathan W Bartlett; Miriam F Moffatt; William O Cookson; Jadwiga Wedzicha; Christopher M Evans; Oliver Lieleg; Patrick Mallia; Sebastian L Johnston
Title: MUC5AC drives COPD exacerbation severity through amplification of virus-induced airway inflammation
  • Document date: 2019_7_22
    • ID: gg2ctmn7_44
    Snippet: The mechanisms underlying virus-induced exacerbations in COPD and the factors that drive inflammation and clinical severity during these episodes are poorly understood. Here, we provide insight into the role that the major airway mucin glycoprotein MUC5AC plays in the biology of these episodes. Using a combination of human and mouse models of rhinovirus infection in COPD, we demonstrate a novel central role of virus-induced MUC5AC in driving COPD.....
    Document: The mechanisms underlying virus-induced exacerbations in COPD and the factors that drive inflammation and clinical severity during these episodes are poorly understood. Here, we provide insight into the role that the major airway mucin glycoprotein MUC5AC plays in the biology of these episodes. Using a combination of human and mouse models of rhinovirus infection in COPD, we demonstrate a novel central role of virus-induced MUC5AC in driving COPD exacerbation severity through amplification of airway inflammation, findings that open up new opportunities for targeting MUC5AC therapeutically. We indicate a mechanism for MUC5AC augmentation of RV-induced inflammation via release of extracellular ATP.

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