Author: Minchen Chien; Thomas K. Anderson; Steffen Jockusch; Chuanjuan Tao; Shiv Kumar; Xiaoxu Li; James J. Russo; Robert Kirchdoerfer; Jingyue Ju
Title: Nucleotide Analogues as Inhibitors of SARS-CoV-2 Polymerase Document date: 2020_3_20
ID: 8prn86g6_1
Snippet: The COVID-19 pandemic, caused by SARS-CoV-2, has now spread to more than 100 countries on 6 continents. SARS-CoV-2 is a new member of the subgenus Sarbecovirus, in the Orthocoronavirinae subfamily, and is distinct from MERS-CoV and SARS-CoV. 1 The coronaviruses are single-strand RNA viruses, sharing properties with other single-stranded RNA viruses such as hepatitis C virus (HCV), West Nile virus, Marburg virus, HIV virus, Ebola virus, dengue vir.....
Document: The COVID-19 pandemic, caused by SARS-CoV-2, has now spread to more than 100 countries on 6 continents. SARS-CoV-2 is a new member of the subgenus Sarbecovirus, in the Orthocoronavirinae subfamily, and is distinct from MERS-CoV and SARS-CoV. 1 The coronaviruses are single-strand RNA viruses, sharing properties with other single-stranded RNA viruses such as hepatitis C virus (HCV), West Nile virus, Marburg virus, HIV virus, Ebola virus, dengue virus, and rhinoviruses. Coronaviruses, like HCV and the flaviviruses, are positive-sense single-strand RNA viruses, 2,3 and these viruses share a similar replication mechanism requiring a RNA-dependent RNA polymerase (RdRp).
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