Author: Tayaza Fadason; Sreemol Gokuladhas; Evgeniia Golovina; Daniel Ho; Sophie Farrow; Denis Nyaga; Hong Pan; Neerja Karnani; Conroy Wong; Antony Cooper; William Schierding; Justin M. O’Sullivan
Title: A transcription regulatory network within the ACE2 locus may promote a pro-viral environment for SARS-CoV-2 by modulating expression of host factors Document date: 2020_4_15
ID: 5r0u2mmo_40
Snippet: that upon viral infection, SARS-COV-2 represses ACE2 expression, which increases the 537 activity of the PIR repressor and CA5B enhancer. This results in a reduction in the production 538 of PIR -the redox switch necessary for NF-κB activation, while also increasing pyrimidine 539 synthesis, which is necessary for viral replication. 540 541 Supplementary Tables 542 S1 The copyright holder for this preprint (which was not peer-reviewed) is the . .....
Document: that upon viral infection, SARS-COV-2 represses ACE2 expression, which increases the 537 activity of the PIR repressor and CA5B enhancer. This results in a reduction in the production 538 of PIR -the redox switch necessary for NF-κB activation, while also increasing pyrimidine 539 synthesis, which is necessary for viral replication. 540 541 Supplementary Tables 542 S1 The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.04.14.042002 doi: bioRxiv preprint specific Hi-C libraries were interrogated to identify genes in fragments that spatially interact 554 (in cis-and trans-) with SNP-containing fragments. The identified spatial SNP-gene pairs were 555 further used to query GTEx lung tissue (dbGaP Accession phs000424.v8.p2, 556
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