Selected article for: "candidate vaccine and efficient vaccine"
Author: Bello, Muhammad Bashir; Yusoff, Khatijah; Ideris, Aini; Hair-Bejo, Mohd; Jibril, Abdurrahman Hassan; Peeters, Ben P. H.; Omar, Abdul Rahman
Title: Exploring the Prospects of Engineered Newcastle Disease Virus in Modern Vaccinology
  • Cord-id: ll1ayjew
  • Document date: 2020_4_16
    • ID: ll1ayjew
    Snippet: Many traditional vaccines have proven to be incapable of controlling newly emerging infectious diseases. They have also achieved limited success in the fight against a variety of human cancers. Thus, innovative vaccine strategies are highly needed to overcome the global burden of these diseases. Advances in molecular biology and reverse genetics have completely restructured the concept of vaccinology, leading to the emergence of state-of-the-art technologies for vaccine design, development and d
    Document: Many traditional vaccines have proven to be incapable of controlling newly emerging infectious diseases. They have also achieved limited success in the fight against a variety of human cancers. Thus, innovative vaccine strategies are highly needed to overcome the global burden of these diseases. Advances in molecular biology and reverse genetics have completely restructured the concept of vaccinology, leading to the emergence of state-of-the-art technologies for vaccine design, development and delivery. Among these modern vaccine technologies are the recombinant viral vectored vaccines, which are known for their incredible specificity in antigen delivery as well as the induction of robust immune responses in the vaccinated hosts. Although a number of viruses have been used as vaccine vectors, genetically engineered Newcastle disease virus (NDV) possesses some useful attributes that make it a preferable candidate for vectoring vaccine antigens. Here, we review the molecular biology of NDV and discuss the reverse genetics approaches used to engineer the virus into an efficient vaccine vector. We then discuss the prospects of the engineered virus as an efficient vehicle of vaccines against cancer and several infectious diseases of man and animals.

    Search related documents:
    Co phrase search for related documents
    • acute respiratory syndrome and adaptive innate immune response: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
    • acute respiratory syndrome and adaptive innate immune response activation: 1
    • acute respiratory syndrome and additional gene: 1, 2, 3, 4, 5, 6, 7
    • acute respiratory syndrome and additional protein: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19
    • adaptive innate and additional gene: 1, 2
    • adaptive innate and additional protein: 1, 2