Author: Danchin, A.; Pagani-Azizi, O.; TURINICI, G.; Yahiaoui, G.
Title: COVID-19 adaptive humoral immunity models: non-neutralizing versus antibody-disease enhancement scenarios Cord-id: kfjv337x Document date: 2020_10_23
ID: kfjv337x
Snippet: The interplay between the virus, infected cells and the immune ressponses to SARS-CoV-2 is still under debate. Extending the basic model of viral dynamics we propose here a formal approach to describe the neutralizing versus non-neutralizing scenarios and compare with the possible effects of antibody-dependent enhancement (ADE). The theoretical model is consistent with data available from the literature and conclusions show that, while both non-neutralizing scenarios and ADE give rise to similar
Document: The interplay between the virus, infected cells and the immune ressponses to SARS-CoV-2 is still under debate. Extending the basic model of viral dynamics we propose here a formal approach to describe the neutralizing versus non-neutralizing scenarios and compare with the possible effects of antibody-dependent enhancement (ADE). The theoretical model is consistent with data available from the literature and conclusions show that, while both non-neutralizing scenarios and ADE give rise to similar final virus clearance, the non-neutralizing antibodies can induce permanent high levels of antibody production with documented unfavorable impact on the disease progression and outcome. We also discuss the implications on secondary infections.
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