Author: Ashish Goyal; E. Fabian Cardozo-Ojeda; Joshua T Schiffer
Title: Potency and timing of antiviral therapy as determinants of duration of SARS CoV-2 shedding and intensity of inflammatory response Document date: 2020_4_14
ID: d7stppv5_25
Snippet: Both high drug potency and extremely early treatment initiation during the presymptomatic stage of infection were required to significantly lower viral area under the curve. Even highly potent therapy during the earliest symptomatic phase at days 4-5 had only a slight impact on viral area under the curve, reflecting the fact that most virus and infected cells are generated during the first 2-3 days of SARS CoV-2 infection (Fig. 5b) ......
Document: Both high drug potency and extremely early treatment initiation during the presymptomatic stage of infection were required to significantly lower viral area under the curve. Even highly potent therapy during the earliest symptomatic phase at days 4-5 had only a slight impact on viral area under the curve, reflecting the fact that most virus and infected cells are generated during the first 2-3 days of SARS CoV-2 infection (Fig. 5b) .
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