Author: Ashish Goyal; E. Fabian Cardozo-Ojeda; Joshua T Schiffer
Title: Potency and timing of antiviral therapy as determinants of duration of SARS CoV-2 shedding and intensity of inflammatory response Document date: 2020_4_14
ID: d7stppv5_51
Snippet: We employed ordinary differential equation models to analyze the in-host SARS CoV-2 dynamics in infected individuals and the potential in vivo effect of different treatment strategies. First, we fit models to the viral load data from different sources using a nonlinear-mixed effects approach. Second, we used pharmacokinetics models to fits observed plasma concentration of remdesivir (RDV) and its active nucleoside triphosphate form in PBMCs, and .....
Document: We employed ordinary differential equation models to analyze the in-host SARS CoV-2 dynamics in infected individuals and the potential in vivo effect of different treatment strategies. First, we fit models to the viral load data from different sources using a nonlinear-mixed effects approach. Second, we used pharmacokinetics models to fits observed plasma concentration of remdesivir (RDV) and its active nucleoside triphosphate form in PBMCs, and blood concentration of hydroxychloroquine (HCQ). Third, we simulated dose response curves for antiviral effect of RDV and HCQ using different possible half maximal effective concentration (EC50) based on in-vitro estimations against SARS-CoV-2. Fourth, we simulated therapy at different times during infection to analyze the potential reduction of SARS CoV-2 shedding. Finally, we repeated projections of therapy including the emergence of resistance to therapy.
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