Author: Es-Saad, Salwa; Tremblay, Nicolas; Baril, Martin; Lamarre, Daniel
Title: Regulators of innate immunity as novel targets for panviral therapeutics Cord-id: nf6ouaq3 Document date: 2012_9_24
ID: nf6ouaq3
Snippet: Interferons (IFNs) have long been used as an immunomodulatory therapy for a large array of acute and chronic viral infections. However, IFN therapies have been plagued by severe side effects. The discovery of pathogen recognition receptors (PRR) rejuvenated the interest for immunomodulatory therapies. The successes obtained with Toll-like receptor (TLR) agonists in activating immune cells and as adjuvant for prophylactic vaccines against different viruses paved the way to targeted immunomodulato
Document: Interferons (IFNs) have long been used as an immunomodulatory therapy for a large array of acute and chronic viral infections. However, IFN therapies have been plagued by severe side effects. The discovery of pathogen recognition receptors (PRR) rejuvenated the interest for immunomodulatory therapies. The successes obtained with Toll-like receptor (TLR) agonists in activating immune cells and as adjuvant for prophylactic vaccines against different viruses paved the way to targeted immunomodulatory therapy. Better characterization of pathogen-induced immune disorders and newly discovered regulators of innate immunity have now the potential to specifically withdraw prevailing subversion mechanisms and to transform antiviral treatments by introducing panviral therapeutics with less adverse effects than IFN therapies.
Search related documents:
Co phrase search for related documents- acid inducible and adaptive immune response: 1, 2, 3, 4, 5
- acid inducible and adaptive immunity: 1, 2
- acid inducible and adaptor protein: 1, 2, 3, 4, 5, 6, 7, 8
- acid inducible gene and activation induce: 1, 2
- acid inducible gene and adaptive immune response: 1, 2, 3, 4, 5
- acid inducible gene and adaptive immunity: 1, 2
- acid inducible gene and adaptor protein: 1, 2, 3, 4, 5, 6, 7, 8
- acid inducible gene retinoic and activation induce: 1, 2
- acid inducible gene retinoic and adaptive immune response: 1, 2, 3, 4, 5
- acid inducible gene retinoic and adaptive immunity: 1, 2
- acid inducible gene retinoic and adaptor protein: 1, 2, 3, 4, 5, 6, 7
- acid sensing and adaptor protein: 1, 2
- act antiviral and activation induce: 1
- act antiviral and adaptive immune response: 1
- act antiviral and adaptive immunity: 1, 2
- activation induce and adaptive immune response: 1, 2, 3, 4
- activation induce and adaptive immunity: 1, 2, 3, 4, 5, 6, 7
- activation induce and adaptor protein: 1, 2
- adaptive immunity and adjuvant agonist: 1
Co phrase search for related documents, hyperlinks ordered by date