Author: Meytal Galilee; Akram Alian
Title: Multimerization of HIV-1 integrase hinges on conserved SH3-docking platforms Document date: 2018_4_16
ID: 4fuxbte0_28
Snippet: Fluorescence based IN activity assays were performed as previously described (30) . Fab was used at a 1:1 molar ratio and the peptide at an excessive ratio of ~ 20 folds. and were processed with iMosflm (31) . The structure was solved by Phaser molecular replacement (32) using IN CCD (PDB code: 1BIS (33)) as a search model. Electron densities were fitted using Coot (34) and refined in the CCP4 suite (35) using REFMAC5 (36) . Structural superposit.....
Document: Fluorescence based IN activity assays were performed as previously described (30) . Fab was used at a 1:1 molar ratio and the peptide at an excessive ratio of ~ 20 folds. and were processed with iMosflm (31) . The structure was solved by Phaser molecular replacement (32) using IN CCD (PDB code: 1BIS (33)) as a search model. Electron densities were fitted using Coot (34) and refined in the CCP4 suite (35) using REFMAC5 (36) . Structural superposition and figures were prepared using PyMOL Molecular Graphics System (Schrödinger, LLC). Table-1 summarizes data collection and refinement statistics.
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