Selected article for: "ace receptor and active infection"
Author: Janice M Leung; Chen Xi Yang; Anthony Tam; Tawimas Shaipanich; Tillie L Hackett; Gurpreet K Singhera; Delbert R Dorscheid; Don D Sin
Title: ACE-2 Expression in the Small Airway Epithelia of Smokers and COPD Patients: Implications for COVID-19
  • Document date: 2020_3_23
    • ID: ei2b8oqn_17
    Snippet: One possibility is differential expression of the ACE-2, which is the main receptor used by SARS-CoV-2 to gain entry into the host mucosa and cause active infection. Here, we investigated gene expression levels of ACE-2 in the airways of individuals with and without COPD and found that COPD and current smokers had significantly increased expression of ACE-2. Importantly, gene expression levels of ACE-2 were inversely related to individual's FEV1,.....
    Document: One possibility is differential expression of the ACE-2, which is the main receptor used by SARS-CoV-2 to gain entry into the host mucosa and cause active infection. Here, we investigated gene expression levels of ACE-2 in the airways of individuals with and without COPD and found that COPD and current smokers had significantly increased expression of ACE-2. Importantly, gene expression levels of ACE-2 were inversely related to individual's FEV1, suggesting a dose-dependent response.

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