Author: Singer, Josef; Le, Nguyen-Son; Mattes, Daniel; Klamminger, Valerie; Hackner, Klaus; Kolinsky, Nicole; Scherb, Michaela; Errhalt, Peter; Kreye, Gudrun; Pecherstorfer, Martin; Vallet, Sonia; Podar, Klaus
Title: Evaluation of Antibody Responses to COVID-19 Vaccines among Solid Tumor and Hematologic Patients Cord-id: knvyorb4 Document date: 2021_8_26
ID: knvyorb4
Snippet: SIMPLE SUMMARY: Vaccination is the primary public health strategy to cope with the COVID-19 pandemic. Although solid tumor and hematologic patients are at higher risk of serious COVID-19-related complications and mortality, data on immune responses to COVID-19 vaccines in this patient cohort are particularly scarce. Our results show that antibody titers against the SARS-CoV-2 spike protein are significantly higher in solid tumor vs. hematologic patients. While SARS-CoV-2 antibody titers were equ
Document: SIMPLE SUMMARY: Vaccination is the primary public health strategy to cope with the COVID-19 pandemic. Although solid tumor and hematologic patients are at higher risk of serious COVID-19-related complications and mortality, data on immune responses to COVID-19 vaccines in this patient cohort are particularly scarce. Our results show that antibody titers against the SARS-CoV-2 spike protein are significantly higher in solid tumor vs. hematologic patients. While SARS-CoV-2 antibody titers were equal among sexes, an age-dependent decrease could be observed. Of note, our studies additionally show that complete vaccination represents a valuable predictor for high anti-SARS-CoV-2 antibody responses in solid tumor and hematologic patients. Our findings aim to support future vaccination strategies in these highly vulnerable patients, including vaccination booster programs and alternative protective approaches. ABSTRACT: Vaccination is the primary public health strategy to cope with the COVID-19 pandemic. Although solid tumor and hematologic patients are at higher risk of serious COVID-19-related complications, data on immune responses to COVID-19 vaccines in this patient cohort are particularly scarce. The present study, therefore, aimed at the standardized determination of anti-SARS-CoV-2 spike protein antibody titers among non-vaccinated versus vaccinated solid tumor and hematologic patients who are under clinical observation or under treatment at the University Hospital Krems. Standardized anti-SARS-CoV-2 S antibody titers of a total of 441 patients were retrospectively analyzed. Our results show that antibody titers against the SARS-CoV-2 spike protein are significantly higher in solid tumor versus hematologic patients. While SARS-CoV-2 antibody titers were equal among sexes, an age-dependent decrease was observed. Of note, our studies additionally show that complete vaccination represents a valuable predictor for high anti-SARS-CoV-2 antibody responses in solid tumor and hematologic patients. In summary, to date, this is one of the largest studies to comprehensively evaluate the impact of various COVID-19 vaccines on anti-SARS-CoV-2 S antibody production in solid tumor and hematologic patients. Our findings aim to support future vaccination strategies in these highly vulnerable patients, including vaccination booster programs and alternative protective approaches.
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