Selected article for: "agar plate and inhibition zone"
Author: Neha Jain; Subodh Kumar Mishra; Uma Shankar; Arpita Tawani; Ankit Jaiswal; Tarun Kumar Sharma; Prashant Kodgire; Amit Kumar
Title: G-quadruplex stabilization in the ions and maltose transporters inhibit Salmonella enterica growth and virulence
  • Document date: 2018_6_27
    • ID: 57xx291v_30
    Snippet: Various small molecules that either stabilized or destabilized the G-quadruplexes conformations are being under investigation for therapeutic intervention of various human pathogenic infection such as BRACO-19, TMPyP4, and several 9-amino acridine derivatives [42] . Previously, 9-amino acridine and its derivatives have been observed for their anti-proliferative properties in cancer cells [53] by binding to the telomeric region [54] , the c-Myc ge.....
    Document: Various small molecules that either stabilized or destabilized the G-quadruplexes conformations are being under investigation for therapeutic intervention of various human pathogenic infection such as BRACO-19, TMPyP4, and several 9-amino acridine derivatives [42] . Previously, 9-amino acridine and its derivatives have been observed for their anti-proliferative properties in cancer cells [53] by binding to the telomeric region [54] , the c-Myc gene [55] and c-Kit promoter [56] . Therefore, here we were interested in analyzing the effect of 9-amino acridine on the S. enterica growth and performed agar disc diffusion assay and MTT assay. A clear zone of inhibition was observed in the agar plate comparable to ampicillin and penicillin (S4 Fig) that suggested the inhibitory effect of 9-amino acridine on the S. enterica growth and an MTT assay observed an IC 50 value of 10.5 μM (Fig 7) .

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