Author: Neha Jain; Subodh Kumar Mishra; Uma Shankar; Arpita Tawani; Ankit Jaiswal; Tarun Kumar Sharma; Prashant Kodgire; Amit Kumar
Title: G-quadruplex stabilization in the ions and maltose transporters inhibit Salmonella enterica growth and virulence Document date: 2018_6_27
ID: 57xx291v_39
Snippet: Considering the suitability of G-quadruplex structure as a promising drug target in both drug susceptible and drug-resistant strain of pathogens, here we sought to search for G-quadruplex motifs in As a concluding remark, the current study shows the presence of stable and highly conserved Gquadruplex structures in essential genes of Salmonella enterica. The 9-amino acridine were observed to bind and reduced the expression of these G-quadruplex st.....
Document: Considering the suitability of G-quadruplex structure as a promising drug target in both drug susceptible and drug-resistant strain of pathogens, here we sought to search for G-quadruplex motifs in As a concluding remark, the current study shows the presence of stable and highly conserved Gquadruplex structures in essential genes of Salmonella enterica. The 9-amino acridine were observed to bind and reduced the expression of these G-quadruplex structure possessing genes and thereby proposed as novel G4 mediated therapeutic approach for combating the infection of Salmonella enterica in humans.
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