Prediction and Evolution of B Cell Epitopes of Surface Protein in SARS-CoV-2

Jerome R Lon; Yunmeng Bai; Bingxu Zhong; Fuqiang Cai; Hongli Du

The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.04.03.022723 doi: bioRxiv preprint region located on the head of the S protein( Figure 3B ), which is the outside of SARS-CoV-2, making it easy to form an epitope. We selected it as a dominant conformational epitope and named it as the epitope E. Additionally, one conformational B-cell epitope(60-65 aa) of E protein was predicted (Table 2) , which is consistent with the epitope F of the E protein. Similarly, this region located on the outside( Figure 3C ), we selected it as a dominant conformational epitope and named G. However, the conformational epitope of the M protein could not be predicted due to the failure of credible homology modeling.