Author: Jiang, Congshan; Li, Xiaowei; Ge, Changrong; Ding, Yuanyuan; Zhang, Tao; Cao, Shuai; Meng, Liesu; Lu, Shemin
Title: Molecular detection of SARS-CoV-2 being challenged by virus variation and asymptomatic infection Cord-id: m2mwxntx Document date: 2021_3_26
ID: m2mwxntx
Snippet: Coronavirus disease 2019 (COVID-19) has been a pandemic for more than a year. With the expanding second wave of pandemic in winter, the continuous evolution of SARS-CoV-2 has brought new issues, including the significance of virus mutations in infection and the detection of asymptomatic infection. In this review, we firstly introduced several major SARS-CoV-2 mutations since the COVID-19 outbreak and then mentioned the widely used molecular detection techniques to diagnose COVID-19, primarily fo
Document: Coronavirus disease 2019 (COVID-19) has been a pandemic for more than a year. With the expanding second wave of pandemic in winter, the continuous evolution of SARS-CoV-2 has brought new issues, including the significance of virus mutations in infection and the detection of asymptomatic infection. In this review, we firstly introduced several major SARS-CoV-2 mutations since the COVID-19 outbreak and then mentioned the widely used molecular detection techniques to diagnose COVID-19, primarily focusing on their strengths and limitations. We further discussed the effects of viral genetic variation and asymptomatic infection on the molecular detection of SARS-CoV-2 infection. The review finally summarized useful insights into the molecular diagnosis of COVID-19 under the special situation challenging by virus mutation and asymptomatic infection.
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