Selected article for: "day time and time change"
Author: Lin, Dan-Yu; Zeng, Donglin; Eron, Joseph J
Title: Evaluating the Efficacy of Therapies in COVID-19 Patients
  • Cord-id: nw69p3rx
  • Document date: 2020_8_21
    • ID: nw69p3rx
    Snippet: There is a proliferation of clinical trials worldwide to find effective therapies for patients diagnosed with novel coronavirus disease-2019 (COVID-19). The endpoints that are currently used to evaluate the efficacy of therapeutic agents against COVID-19 are focused on clinical status at a particular day or on time to a specific change of clinical status. To provide a full picture of the clinical course of a patient and make complete use of available data, we consider the trajectory of clinical
    Document: There is a proliferation of clinical trials worldwide to find effective therapies for patients diagnosed with novel coronavirus disease-2019 (COVID-19). The endpoints that are currently used to evaluate the efficacy of therapeutic agents against COVID-19 are focused on clinical status at a particular day or on time to a specific change of clinical status. To provide a full picture of the clinical course of a patient and make complete use of available data, we consider the trajectory of clinical status over the entire follow-up period. We also show how to combine the evidence of treatment effects on the occurrences of various clinical events. We compare the proposed and existing endpoints through extensive simulation studies. Finally, we provide guidelines on establishing the benefits of treatments.

    Search related documents:
    Co phrase search for related documents
    • accurate assessment and acute respiratory distress syndrome develop: 1
    • accurate assessment and logistic model: 1
    • acute respiratory distress syndrome and logistic model: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24
    • acute respiratory distress syndrome and low probability: 1, 2
    • acute respiratory distress syndrome and low severity: 1, 2, 3, 4, 5, 6, 7
    • acute respiratory distress syndrome develop and low severity: 1
    • logistic model and low probability: 1, 2
    • logistic model and low severity: 1, 2