Author: S. Willis; J. Masel
Title: Gene birth contributes to structural disorder encoded by overlapping genes Document date: 2017_12_6
ID: 9w2wjiik_61
Snippet: There is growing interest in the topic of de novo gene birth, but identifying de novo genes is plagued with high rates of both false positives and false negatives [24] , with phylostratigraphy tools being particularly controversial due to homology detection biases [28] . The overlapping viral genes that we study are unlikely either to be non-genes, and must have arisen via de novo gene birth, and so circumvent many of these difficulties. [8] have.....
Document: There is growing interest in the topic of de novo gene birth, but identifying de novo genes is plagued with high rates of both false positives and false negatives [24] , with phylostratigraphy tools being particularly controversial due to homology detection biases [28] . The overlapping viral genes that we study are unlikely either to be non-genes, and must have arisen via de novo gene birth, and so circumvent many of these difficulties. [8] have disputed that young genes have high ISD, in an analysis that was prone to false positives [52] ; our findings here provide an independent line of evidence, free from the danger of homology detection bias, that younger genes have higher ISD.
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