Author: S. Willis; J. Masel
Title: Gene birth contributes to structural disorder encoded by overlapping genes Document date: 2017_12_6
ID: 9w2wjiik_63
Snippet: More broadly, our results are consistent with a major role for mutational availability in shaping adaptive evolution. Rare adaptive changes happen at a rate given by the product of mutation and the probability of fixation, with the latter proportional to the selection coefficient [23] . This means that differences in the beneficial mutation rate are just as important as differences in the selection coefficient in determining which path adaptive e.....
Document: More broadly, our results are consistent with a major role for mutational availability in shaping adaptive evolution. Rare adaptive changes happen at a rate given by the product of mutation and the probability of fixation, with the latter proportional to the selection coefficient [23] . This means that differences in the beneficial mutation rate are just as important as differences in the selection coefficient in determining which path adaptive evolution takes [54] . The influence of mutational bias has previously been observed for beneficial mutations to single amino acids in the laboratory [41] , [46] and in the wild [45] . Here we demonstrate it for more radical mutations, namely the de novo birth of entire proteincoding genes. . CC-BY-NC-ND 4.0 International license is made available under a The copyright holder for this preprint (which was not peer-reviewed) is the author/funder. It . https://doi.org/10.1101/229690 doi: bioRxiv preprint
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