Author: S. Willis; J. Masel
Title: Gene birth contributes to structural disorder encoded by overlapping genes Document date: 2017_12_6
ID: 9w2wjiik_7
Snippet: Young genes are known to have higher ISD than old genes, with high ISD at the moment of gene birth facilitating the process [52] , perhaps because cells tolerate them better [48] . Domains that were more recently born de novo also have higher ISD [3] , [5] , [14] , [26] . High ISD could be helpful in itself in creating novel function, or it could be a byproduct of a hydrophilic amino acid composition whose function is simply the avoidance of harm.....
Document: Young genes are known to have higher ISD than old genes, with high ISD at the moment of gene birth facilitating the process [52] , perhaps because cells tolerate them better [48] . Domains that were more recently born de novo also have higher ISD [3] , [5] , [14] , [26] . High ISD could be helpful in itself in creating novel function, or it could be a byproduct of a hydrophilic amino acid composition whose function is simply the avoidance of harmful protein aggregation [16] , [22] . Regardless of the cause of high ISD in young genes, the "facilitate birth" hypothesis makes a distinct prediction from the constraint hypothesis, namely that the novel overlapping reading frames will tend to encode higher ISD than the ancestral overlapping reading frames.
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