Author: Yadi Zhou; Yuan Hou; Jiayu Shen; Yin Huang; William Martin; Feixiong Cheng
Title: Network-based Drug Repurposing for Human Coronavirus Document date: 2020_2_5
ID: b4mdiont_45
Snippet: types. An early study showed that dactinomycin (1 microgram/ml) inhibited the growth of feline enteric CoV [63] . As shown in Figure 6B , our network analysis shows that sirolimus and dactinomycin synergistically target HCoV-associated host protein subnetwork by 'Complementary Exposure' pattern, offering potential combination regimens for treatment of HCoV. Specifically, sirolimus and dactinomycin may inhibit both mTOR signaling and RNA synthesis.....
Document: types. An early study showed that dactinomycin (1 microgram/ml) inhibited the growth of feline enteric CoV [63] . As shown in Figure 6B , our network analysis shows that sirolimus and dactinomycin synergistically target HCoV-associated host protein subnetwork by 'Complementary Exposure' pattern, offering potential combination regimens for treatment of HCoV. Specifically, sirolimus and dactinomycin may inhibit both mTOR signaling and RNA synthesis pathway (including DNA topoisomerase 2-alpha (TOP2A) and DNA topoisomerase 2-beta (TOP2B)) in HCoV infected cells ( Figure 6B ).
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