Author: Yadi Zhou; Yuan Hou; Jiayu Shen; Yin Huang; William Martin; Feixiong Cheng
Title: Network-based Drug Repurposing for Human Coronavirus Document date: 2020_2_5
ID: b4mdiont_49
Snippet: is the (which was not peer-reviewed) The copyright holder for this preprint . https://doi.org/10.1101/2020.02.03.20020263 doi: medRxiv preprint viral infection via its anti-inflammatory and antioxidant effects [55] [56] [57] [58] [59] . Melatonin indirectly regulates ACE2 expression, a key entry receptor involved in viral infection of HCoVs, including 2019-nCoV [31] . JUN, also known as c-Jun, is a key host protein involving in HCoV infectious br.....
Document: is the (which was not peer-reviewed) The copyright holder for this preprint . https://doi.org/10.1101/2020.02.03.20020263 doi: medRxiv preprint viral infection via its anti-inflammatory and antioxidant effects [55] [56] [57] [58] [59] . Melatonin indirectly regulates ACE2 expression, a key entry receptor involved in viral infection of HCoVs, including 2019-nCoV [31] . JUN, also known as c-Jun, is a key host protein involving in HCoV infectious bronchitis virus [68] . As shown in Figure 6D , mercaptopurine and melatonin may synergistically block c-Jun signaling by targeting multiple cellular targets.
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