Author: Kuri-Cervantes, Leticia; Pampena, M. Betina; Meng, Wenzhao; Rosenfeld, Aaron M.; Ittner, Caroline A.G.; Weisman, Ariel R.; Agyekum, Roseline; Mathew, Divij; Baxter, Amy E.; Vella, Laura; Kuthuru, Oliva; Apostolidis, Sokratis; Bershaw, Luanne; Dougherty, Jeannete; Greenplate, Allison R.; Pattekar, Ajinkya; Kim, Justin; Han, Nicholas; Gouma, Sigrid; Weirick, Madison E.; Arevalo, Claudia P.; Bolton, Marcus J.; Goodwin, Eileen C.; Anderson, Elizabeth M.; Hensley, Scott E.; Jones, Tiffanie K.; Mangalmurti, Nilam S.; Luning Prak, Eline T.; Wherry, E. John; Meyer, Nuala J.; Betts, Michael R.
Title: Immunologic perturbations in severe COVID-19/SARS-CoV-2 infection Cord-id: mdsjbfmx Document date: 2020_5_18
ID: mdsjbfmx
Snippet: Although critical illness has been associated with SARS-CoV-2-induced hyperinflammation, the immune correlates of severe COVID-19 remain unclear. Here, we comprehensively analyzed peripheral blood immune perturbations in 42 SARS-CoV-2 infected and recovered individuals. We identified broad changes in neutrophils, NK cells, and monocytes during severe COVID-19, suggesting excessive mobilization of innate lineages. We found marked activation within T and B cells, highly oligoclonal B cell populati
Document: Although critical illness has been associated with SARS-CoV-2-induced hyperinflammation, the immune correlates of severe COVID-19 remain unclear. Here, we comprehensively analyzed peripheral blood immune perturbations in 42 SARS-CoV-2 infected and recovered individuals. We identified broad changes in neutrophils, NK cells, and monocytes during severe COVID-19, suggesting excessive mobilization of innate lineages. We found marked activation within T and B cells, highly oligoclonal B cell populations, profound plasmablast expansion, and SARS-CoV-2-specific antibodies in many, but not all, severe COVID-19 cases. Despite this heterogeneity, we found selective clustering of severe COVID-19 cases through unbiased analysis of the aggregated immunological phenotypes. Our findings demonstrate broad immune perturbations spanning both innate and adaptive leukocytes that distinguish dysregulated host responses in severe SARS-CoV-2 infection and warrant therapeutic investigation. One Sentence Summary Broad immune perturbations in severe COVID-19
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