Author: Ashish Goyal; E. Fabian Cardozo-Ojeda; Joshua T Schiffer
Title: Potency and timing of antiviral therapy as determinants of duration of SARS CoV-2 shedding and intensity of inflammatory response Document date: 2020_4_14
ID: d7stppv5_108
Snippet: Each set of simulations is performed under assumptions of high, medium and low potency. Treatment initiation is at timepoints generally consistent with a. hospitalization (day 10 after first positive sample), b. first symptoms (day 5 after first positive sample), c. pre-symptomatic post-peak phase (day 2 after first positive sample) and d. presymptomatic pre-peak phase (day 0). Overall, early potent treatment limits duration of infection. Heatmap.....
Document: Each set of simulations is performed under assumptions of high, medium and low potency. Treatment initiation is at timepoints generally consistent with a. hospitalization (day 10 after first positive sample), b. first symptoms (day 5 after first positive sample), c. pre-symptomatic post-peak phase (day 2 after first positive sample) and d. presymptomatic pre-peak phase (day 0). Overall, early potent treatment limits duration of infection. Heatmaps comparing variance in bNAb potency measured by in vivo EC50 (x-axis) and timing of treatment initiation (y-axis) for e. Shedding duration, f. viral load area under the curve (AUC) and g. extent of T cell response required for viral elimination.
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