Selected article for: "drug target and virus binding"
Author: Chen, Zhaoyu; Cui, Qinghua; Caffrey, Michael; Rong, Lijun; Du, Ruikun
Title: Small Molecule Inhibitors of Influenza Virus Entry
  • Cord-id: ot8m4rxi
  • Document date: 2021_6_18
    • ID: ot8m4rxi
    Snippet: Hemagglutinin (HA) plays a critical role during influenza virus receptor binding and subsequent membrane fusion process, thus HA has become a promising drug target. For the past several decades, we and other researchers have discovered a series of HA inhibitors mainly targeting its fusion machinery. In this review, we summarize the advances in HA-targeted development of small molecule inhibitors. Moreover, we discuss the structural basis and mode of action of these inhibitors, and speculate upon
    Document: Hemagglutinin (HA) plays a critical role during influenza virus receptor binding and subsequent membrane fusion process, thus HA has become a promising drug target. For the past several decades, we and other researchers have discovered a series of HA inhibitors mainly targeting its fusion machinery. In this review, we summarize the advances in HA-targeted development of small molecule inhibitors. Moreover, we discuss the structural basis and mode of action of these inhibitors, and speculate upon future directions toward more potent inhibitors of membrane fusion and potential anti-influenza drugs.

    Search related documents:
    Co phrase search for related documents
    • achieve difficult and acute respiratory syndrome coronavirus: 1, 2
    • achieve difficult and low toxicity: 1, 2, 3
    • action binding and acute respiratory syndrome coronavirus: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14
    • action binding and luciferase assay: 1
    • action binding mode and acute respiratory syndrome coronavirus: 1, 2
    • action different mechanism and acute respiratory syndrome coronavirus: 1, 2
    • action mechanism and acute respiratory syndrome coronavirus: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72
    • action mechanism and low toxicity: 1, 2, 3, 4, 5, 6, 7
    • action mechanism and luciferase assay: 1, 2, 3, 4
    • action mechanism moa and acute respiratory syndrome coronavirus: 1
    • action mechanism moa and low toxicity: 1