Selected article for: "AUC curve viral load area and treatment initiation"
Author: Ashish Goyal; E. Fabian Cardozo-Ojeda; Joshua T Schiffer
Title: Potency and timing of antiviral therapy as determinants of duration of SARS CoV-2 shedding and intensity of inflammatory response
  • Document date: 2020_4_14
    • ID: d7stppv5_95
    Snippet: Heatmaps comparing variance in drug potency measured by in vivo EC50 (x-axis) and timing of treatment initiation (y-axis) for A. Shedding duration, B. viral load area under the curve (AUC) and C. extent of T cell response required for viral elimination. Potent therapy within the first 5 days of infection limits shedding duration and the extent of the T cell response. However, only extremely early therapy during the pre-symptomatic phase of infect.....
    Document: Heatmaps comparing variance in drug potency measured by in vivo EC50 (x-axis) and timing of treatment initiation (y-axis) for A. Shedding duration, B. viral load area under the curve (AUC) and C. extent of T cell response required for viral elimination. Potent therapy within the first 5 days of infection limits shedding duration and the extent of the T cell response. However, only extremely early therapy during the pre-symptomatic phase of infection lowers viral AUC. Sub-potent therapy given during the extremely early pre-symptomatic stage may extend shedding duration at lower viral loads by limiting the effector cell response.

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