Author: Danielle E Anderson; Jin Cui; Qian Ye; Baoying Huang; Wenhong Zu; Jing Gong; Weiqiang Liu; So Young Kim; Biao Guo Yan; Kristmundur Sigmundsson; Xiao Fang Lim; Fei Ye; Peihua Niu; Xuming Zhou; Wenjie Tan; Lin-Fa Wang; Xu Tan
Title: Orthogonal genome-wide screenings in bat cells identify MTHFD1 as a target of broad antiviral therapy Document date: 2020_3_30
ID: 0l33i6s4_33
Snippet: Formyl THF synthetase active site (F759A/W788A, or FW/AA) 32 completely abolished this rescue, 14 further supporting that the purine synthesis activity of MTHFD1 is an essential activity for viral 15 replication (Fig. 3b, 3f and 3g) . 16.....
Document: Formyl THF synthetase active site (F759A/W788A, or FW/AA) 32 completely abolished this rescue, 14 further supporting that the purine synthesis activity of MTHFD1 is an essential activity for viral 15 replication (Fig. 3b, 3f and 3g) . 16
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