Selected article for: "infected people and viral elimination"
Author: Ashish Goyal; E. Fabian Cardozo-Ojeda; Joshua T Schiffer
Title: Potency and timing of antiviral therapy as determinants of duration of SARS CoV-2 shedding and intensity of inflammatory response
  • Document date: 2020_4_14
    • ID: d7stppv5_16
    Snippet: We next simulated therapy at day 10 of infection (Fig. 4a) , when severely infected people often seek hospital care, and at day 5 of infection immediately after viral peak (Fig. 4b) , when infected people often become symptomatic. In both cases, when remdesivir in vivo potency was assumed to be high (EC50=0.8 uM), viral elimination occurred rapidly after initiation of therapy. This effect occurred because of unopposed removal of approximately 100.....
    Document: We next simulated therapy at day 10 of infection (Fig. 4a) , when severely infected people often seek hospital care, and at day 5 of infection immediately after viral peak (Fig. 4b) , when infected people often become symptomatic. In both cases, when remdesivir in vivo potency was assumed to be high (EC50=0.8 uM), viral elimination occurred rapidly after initiation of therapy. This effect occurred because of unopposed removal of approximately 100-1000 infected cells per day by an ongoing innate immune response (Fig. 2b) .

    Search related documents:
    Co phrase search for related documents