Author: Peng, Yumeng; Wan, Luming; Fan, Chen; Zhang, Pingping; Wang, Xiaolin; Sun, Jin; Zhang, Yanhong; Yan, Qiulin; Gong, Jing; Yang, Huan; Yang, Xiaopan; Li, Huilong; Wang, Yufei; Zong, Yulong; Yin, Feng; Yang, Xiaoli; Zhong, Hui; Cao, Yuan; Wei, Congwen
Title: Cholesterol Metabolism--Impact for SARS-CoV-2 Infection Prognosis, Entry, and Antiviral Therapies Cord-id: mmnfyz6y Document date: 2020_4_22
ID: mmnfyz6y
Snippet: In this study, we specifically addressed the connection between the SARS-CoV-2 virus with host cholesterol metabolism. Plasma lipid profile was measured in 861 COVID-19 patients classified as mild (n=215), moderate (n=364), severe (n=217) or critical (n=65) and 1108 age- and sex-matched healthy individuals. We showed that the levels of both TG and HDL-C were significantly lower in patients with severe disease than in patients with moderate or mild disease. After successful treatment, cholesterol
Document: In this study, we specifically addressed the connection between the SARS-CoV-2 virus with host cholesterol metabolism. Plasma lipid profile was measured in 861 COVID-19 patients classified as mild (n=215), moderate (n=364), severe (n=217) or critical (n=65) and 1108 age- and sex-matched healthy individuals. We showed that the levels of both TG and HDL-C were significantly lower in patients with severe disease than in patients with moderate or mild disease. After successful treatment, cholesterol metabolism was reestablished in patients with SARS-CoV-2 infection. The serum concentrations of TC and HDL-C can be used as indicators of disease severity and prognosis in COVID-19 patients.
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