Author: Cazottes, Emmanuel; Rougeulle, Claire
Title: Straight to the X: Modeling Human X Chromosome Inactivation in hESCs by FGF Signal Blockade. Cord-id: mnseb4tb Document date: 2020_9_3
ID: mnseb4tb
Snippet: In this issue of Cell Stem Cell, An et al. (2020) provide a model to study human X chromosome inactivation. They followed X chromosome activity and traced cellular heterogeneity in naive hESCS, showed that it is caused by incomplete blockade of FGF-signaling, and in doing so isolated cells resembling pre-implantation epiblasts.
Document: In this issue of Cell Stem Cell, An et al. (2020) provide a model to study human X chromosome inactivation. They followed X chromosome activity and traced cellular heterogeneity in naive hESCS, showed that it is caused by incomplete blockade of FGF-signaling, and in doing so isolated cells resembling pre-implantation epiblasts.
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