Half‐year follow‐up of patients recovering from severe COVID‐19: Analysis of symptoms and their risk factors

Shang, Y. F.; Liu, T.; Yu, J. N.; Xu, X. R.; Zahid, K. R.; Wei, Y. C.; Wang, X. H.; Zhou, F. L.

OBJECTIVES: To understand the sequelae of COVID‐19. METHODS: We followed up 1174 patients with severe coronavirus disease 2019 (COVID‐19)who were recovered and discharged for 6 months. RESULTS: There were 175 cases with clear IgG results 6 months after discharge, of which 82 (46.9%) were IgG (+) and 16 (9.1%) were IgG (dim+). Four hundred and forty‐one participants (55.4%) had some kind of sequelae. The most common symptoms were fatigue (25.3%), sleep disorder (23.2%) and shortness of breath (20.4%). In those who had sequelae, 262 (59.4%) had more than one symptom. Critical cases were more likely to have cough (20.5% vs 11.6%, p = 0.023) and hypomnesis (15.1% vs 8.0%, p = 0.041) than severe cases. Furthermore, univariate and multivariate logistic regression analyses revealed that women are more likely to have multiple symptoms (p = 0.002), fatigue (p = 0.009) and sleep disorder (p = 0.008), whereas critical illness was found as independent risk factor for hypomnesis (p = 0.045). CONCLUSION: Our study demonstrated the duration of antibody and sequelae of COVID‐19 and compared the differences amongst different populations.