Author: Darko Bosnakovski; Erik A. Toso; Olivia O. Recht; Anja Cucak; Abhinav K Jain; Michelle C. Barton; Michael Kyba
Title: p53 is not necessary for DUX4 pathology Document date: 2017_3_19
ID: jopeo9gs_16
Snippet: Using both the inducible C2C12 cell culture system, where it was originally demonstrated that DUX4 was pathogenic to myogenic progenitors (Bosnakovski et al. 2008) , and the iDUX4[2.7] mouse model (Dandapat et al. 2014 ), we find no evidence for p53 involvement in DUX4 pathogenicity. Interestingly, this applies to phenotypes caused by very low basal levels of DUX4 expression, as the developmental effects and runting are thought to be, as well as .....
Document: Using both the inducible C2C12 cell culture system, where it was originally demonstrated that DUX4 was pathogenic to myogenic progenitors (Bosnakovski et al. 2008) , and the iDUX4[2.7] mouse model (Dandapat et al. 2014 ), we find no evidence for p53 involvement in DUX4 pathogenicity. Interestingly, this applies to phenotypes caused by very low basal levels of DUX4 expression, as the developmental effects and runting are thought to be, as well as overt cytotoxicity in primary or immortalized cells, which is the result of high level DUX4 expression.
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